Friday, February 19, 2016

Maverakis Lab Publications

Manuscripts of special interest are in Purple
Highly downloaded papers have accompanying Altmetric Scores


Marusina AI, Ono Y, Merleev AA, Shimoda M, Ogawa H, Wang EA, Kondo K, Olney L, Luxardi G, Miyamura Y, Yilma TD, Villalobos IB, Bergstrom JW, Kronenberg DG, Soulika AM, Adamopoulos IE, Maverakis E. CD4+ virtual memory: Antigen-inexperienced T cells reside in the naive, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity. J Autoimmun. 2016.10.1016/j.jaut.2016.11.001

Raychaudhuri SP, Wilken R, Sukhov AC, Raychaudhuri SK, Maverakis E. Management of psoriatic arthritis: Early diagnosis, monitoring of disease severity and cutting edge therapies. J Autoimmun. 2017;76:21-37.10.1016/j.jaut.2016.10.009



Wilken R, Sharma A, Patel F, Maverakis E. Successful treatment of palmoplantar pustulosis with isotretinoin. Dermatol Online J. 2015;21(8)

Wilken R, Li CS, Sharon VR, Kim K, Patel FB, Patel F, Maverakis E. Topical clobetasol for the treatment of toxic epidermal necrolysis: study protocol for a randomized controlled trial. Trials. 2015;16:374.10.1186/s13063-015-0879-7

Shi VY, Tran K, Patel F, Leventhal J, Konia T, Fung MA, Wilken R, Garcia MS, Fitzmaurice SD, Joo J, Monjazeb AM, Burrall BA, King B, Martinez S, Christensen SD, Maverakis E. 100% Complete response rate in patients with cutaneous metastatic melanoma treated with intralesional interleukin (IL)-2, imiquimod, and topical retinoid combination therapy: results of a case series. J Am Acad Dermatol. 2015;73(4):645-654.10.1016/j.jaad.2015.06.060

Patel F, Fitzmaurice S, Duong C, He Y, Fergus J, Raychaudhuri SP, Garcia MS, Maverakis E. Effective strategies for the management of pyoderma gangrenosum: a comprehensive review. Acta Derm Venereol. 2015;95(5):525-531.10.2340/00015555-2008

Park D, Brune KA, Mitra A, Marusina AI, Maverakis E, Lebrilla CB. Characteristic Changes in Cell Surface Glycosylation Accompany Intestinal Epithelial Cell (IEC) Differentiation: High Mannose Structures Dominate the Cell Surface Glycome of Undifferentiated Enterocytes. Mol Cell Proteomics. 2015;14(11):2910-2921.10.1074/mcp.M115.053983

Mitra A, Luna JI, Marusina AI, Merleev A, Kundu-Raychaudhuri S, Fiorentino D, Raychaudhuri SP, Maverakis E. Dual mTOR Inhibition Is Required to Prevent TGF-beta-Mediated Fibrosis: Implications for Scleroderma. J Invest Dermatol. 2015;135(11):2873-2876.10.1038/jid.2015.252

Maverakis E, Kim K, Shimoda M, Gershwin ME, Patel F, Wilken R, Raychaudhuri S, Ruhaak LR, Lebrilla CB. Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: a critical review. J Autoimmun. 2015;57:1-13.10.1016/j.jaut.2014.12.002

Maverakis E, Cornelius LA, Bowen GM, Phan T, Patel FB, Fitzmaurice S, He Y, Burrall B, Duong C, Kloxin AM, Sultani H, Wilken R, Martinez SR, Patel F. Metastatic melanoma - a review of current and future treatment options. Acta Derm Venereol. 2015;95(5):516-524.10.2340/00015555-2035

Hong Q, Ruhaak LR, Stroble C, Parker E, Huang J, Maverakis E, Lebrilla CB. A Method for Comprehensive Glycosite-Mapping and Direct Quantitation of Serum Glycoproteins. J Proteome Res. 2015;14(12):5179-5192.10.1021/acs.jproteome.5b00756

He Y, Shimoda M, Ono Y, Villalobos IB, Mitra A, Konia T, Grando SA, Zone JJ, Maverakis E. Persistence of Autoreactive IgA-Secreting B Cells Despite Multiple Immunosuppressive Medications Including Rituximab. JAMA Dermatol. 2015;151(6):646-650.10.1001/jamadermatol.2015.59

Adamopoulos IE, Suzuki E, Chao CC, Gorman D, Adda S, Maverakis E, Zarbalis K, Geissler R, Asio A, Blumenschein WM, McClanahan T, De Waal Malefyt R, Gershwin ME, Bowman EP. IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis. Ann Rheum Dis. 2015;74(6):1284-1292.10.1136/annrheumdis-2013-204782


Armstrong AW, Johnson MA, Lin S, Maverakis E, Fazel N, Liu FT. Patient-centered, direct-access online care for management of atopic dermatitis: a randomized clinical trial. JAMA Dermatol. 2015;151(2):154-160.10.1001/jamadermatol.2014.2299

Wu DJ, Dixit N, Suzuki E, Nguyen T, Shin HS, Davis J, Maverakis E, Adamopoulos IE. A novel in vivo gene transfer technique and in vitro cell based assays for the study of bone loss in musculoskeletal disorders. J Vis Exp. 2014(88).10.3791/51810

Sharon V, Burrall B, Patel F, He Y, Konia T, Villalobos IB, Maverakis E. Multimodal therapy of idiopathic pyoderma gangrenosum. Dermatol Online J. 2014;20(6)

Raychaudhuri SK, Maverakis E, Raychaudhuri SP. Diagnosis and classification of psoriasis. Autoimmun Rev. 2014;13(4-5):490-495.10.1016/j.autrev.2014.01.008

Patel F, Wilken R, Burrall B, Martinez S, Wells V, King B, Maverakis E. Detailed protocol for administration of intralesional IL-2 for the treatment of Stage IIIc and IV M1a metastatic melanoma based on current NCCN guidelines. Dermatol Online J. 2014;20(11)

Mirsoian A, Bouchlaka MN, Sckisel GD, Chen M, Pai CC, Maverakis E, Spencer RG, Fishbein KW, Siddiqui S, Monjazeb AM, Martin B, Maudsley S, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Taub DD, Murphy WJ. Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. J Exp Med. 2014;211(12):2373-2383.10.1084/jem.20140116

Maverakis E, Patel F, Kronenberg DG, Chung L, Fiorentino D, Allanore Y, Guiducci S, Hesselstrand R, Hummers LK, Duong C, Kahaleh B, Macgregor A, Matucci-Cerinic M, Wollheim FA, Mayes MD, Gershwin ME. International consensus criteria for the diagnosis of Raynaud's phenomenon. J Autoimmun. 2014;48-49:60-65.10.1016/j.jaut.2014.01.020

Maverakis E, He Y, Patel FB, Fitzmaurice S, Fung MA. Mycobacterium chelonae infection presenting as recurrent cutaneous and subcutaneous nodules--a presentation previously diagnosed as Weber Christian disease. Dermatol Online J. 2014;20(6)

Prior to 2013

Sivamani RK, Goodarzi H, Garcia MS, Raychaudhuri SP, Wehrli LN, Ono Y, Maverakis E. Biologic therapies in the treatment of psoriasis: a comprehensive evidence-based basic science and clinical review and a practical guide to tuberculosis monitoring. Clin Rev Allergy Immunol. 2013;44(2):121-140.10.1007/s12016-012-8301-7

Shah DR, Yang AD, Maverakis E, Martinez SR. Assessing rural-urban disparities in the use of sentinel lymph node biopsy for melanoma. J Surg Res. 2013;184(2):1157-1160.10.1016/j.jss.2013.04.091

Shah DR, Yang AD, Maverakis E, Martinez SR. Age-related disparities in use of completion lymphadenectomy for melanoma sentinel lymph node metastasis. J Surg Res. 2013;185(1):240-244.10.1016/j.jss.2013.05.090

Patel F, Marusina AI, Duong C, Adamopoulos IE, Maverakis E. NKG2C, HLA-E and their association with psoriasis. Exp Dermatol. 2013;22(12):797-799.10.1111/exd.12280

Martinez SR, Shah DR, Yang AD, Canter RJ, Maverakis E. Sentinel lymph node biopsy in patients with thick primary cutaneous melanoma: patterns of use and underuse utilizing a population-based model. ISRN Dermatol. 2013;2013:315609.10.1155/2013/315609

He Y, Maverakis E, Ramirez-Maverakis D, Fitzmaurice S. Combination therapy with intralesional triamcinolone and oral dapsone for management of palisaded neutrophilic and granulomatous dermatitis. Dermatol Online J. 2013;19(2):17

Bouchlaka MN, Sckisel GD, Chen M, Mirsoian A, Zamora AE, Maverakis E, Wilkins DE, Alderson KL, Hsiao HH, Weiss JM, Monjazeb AM, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Redelman D, Taub DD, Murphy WJ. Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J Exp Med. 2013;210(11):2223-2237.10.1084/jem.20131219

Sivamani RK, Ma BR, Wehrli LN, Maverakis E. Phytochemicals and Naturally Derived Substances for Wound Healing. Adv Wound Care (New Rochelle). 2012;1(5):213-217.10.1089/wound.2011.0330

Sharon VR, Garcia MS, Bagheri S, Goodarzi H, Yang C, Ono Y, Maverakis E. Management of recalcitrant hidradenitis suppurativa with ustekinumab. Acta Derm Venereol. 2012;92(3):320-321.10.2340/00015555-1229

Revzin A, Maverakis E, Chang HC. Biosensors for immune cell analysis-A perspective. Biomicrofluidics. 2012;6(2):21301-2130113.10.1063/1.4706845

Maverakis E, Li CS, Alikhan A, Lin TC, Idriss N, Armstrong AW. The effect of academic "misrepresentation" on residency match outcomes. Dermatol Online J. 2012;18(1):1

Maverakis E, Goodarzi H, Wehrli LN, Ono Y, Garcia MS. The etiology of paraneoplastic autoimmunity. Clin Rev Allergy Immunol. 2012;42(2):135-144.10.1007/s12016-010-8248-5

Maverakis E. Sercarzian immunology--In memoriam. Eli E. Sercarz, 1934-2009. Cell Immunol. 2012;273(2):99-108.10.1016/j.cellimm.2011.12.009

Martinez SR, Shah DR, Maverakis E, Yang AD. Geographic variation in utilization of sentinel lymph node biopsy for intermediate thickness cutaneous melanoma. J Surg Oncol. 2012;106(7):807-810.10.1002/jso.23169

Loh E, Maverakis E, Konia T, Noll E. Lepromatous leprosy in a 26-year-old man with concurrent disseminated tuberculosis. Arch Dermatol. 2012;148(9):1096-1097.10.1001/archdermatol.2012.970

Loh E, Fung MA, Maverakis E. Acute guttate psoriasis in a 15-year-old girl with Epstein-Barr virus infection. Arch Dermatol. 2012;148(5):658-659.10.1001/archdermatol.2011.3517

Guo W, Liu R, Ono Y, Ma AH, Martinez A, Sanchez E, Wang Y, Huang W, Mazloom A, Li J, Ning J, Maverakis E, Lam KS, Kung HJ. Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol Pharmacol. 2012;82(5):938-947.10.1124/mol.112.079889

Goodarzi H, Sivamani RK, Garcia MS, Wehrli LN, Craven H, Ono Y, Maverakis E. Effective Strategies for the Management of Pyoderma Gangrenosum. Adv Wound Care (New Rochelle). 2012;1(5):194-199.10.1089/wound.2011.0339

Bouchlaka MN, Sckisel GD, Wilkins D, Maverakis E, Monjazeb AM, Fung M, Welniak L, Redelman D, Fuchs A, Evrensel CA, Murphy WJ. Mechanical disruption of tumors by iron particles and magnetic field application results in increased anti-tumor immune responses. PLoS One. 2012;7(10):e48049.10.1371/journal.pone.0048049

Zhang W, Ono Y, Miyamura Y, Bowlus CL, Gershwin ME, Maverakis E. T cell clonal expansions detected in patients with primary biliary cirrhosis express CX3CR1. J Autoimmun. 2011;37(2):71-78.10.1016/j.jaut.2011.05.009

Rudolph M, Hebel K, Miyamura Y, Maverakis E, Brunner-Weinzierl MC. Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T cells in vivo. J Immunol. 2011;186(10):5580-5589.10.4049/jimmunol.1003381

He Y, Merin MR, Sharon VR, Maverakis E. Eruptive keloids associated with breast cancer: a paraneoplastic phenomenon? Acta Derm Venereol. 2011;91(4):480-481.10.2340/00015555-1089

Garcia MS, Ono Y, Martinez SR, Chen SL, Goodarzi H, Phan T, Wehrli LN, Miyamura Y, Fung MA, Maverakis E. Complete regression of subcutaneous and cutaneous metastatic melanoma with high-dose intralesional interleukin 2 in combination with topical imiquimod and retinoid cream. Melanoma Res. 2011;21(3):235-243.10.1097/CMR.0b013e328345e95e

Takada Y, Ono Y, Saegusa J, Mitsiades C, Mitsiades N, Tsai J, He Y, Maningding E, Coleman A, Ramirez-Maverakis D, Rodrigues R, Takada Y, Maverakis E. A T cell-binding fragment of fibrinogen can prevent autoimmunity. J Autoimmun. 2010;34(4):453-459.10.1016/j.jaut.2009.11.017

Sivamani RK, Correa G, Ono Y, Bowen MP, Raychaudhuri SP, Maverakis E. Biological therapy of psoriasis. Indian J Dermatol. 2010;55(2):161-170.10.4103/0019-5154.62754

Maverakis E, Miyamura Y, Bowen MP, Correa G, Ono Y, Goodarzi H. Light, including ultraviolet.
J Autoimmun. 2010;34(3):J247-257.10.1016/j.jaut.2009.11.011
Maverakis E, Menezes JS, Ametani A, Han M, Stevens DB, He Y, Wang Y, Ono Y, Miyamura Y, Lam KS, Ward ES, Sercarz EE. Molecular mimics can induce a nonautoaggressive repertoire that preempts induction of autoimmunity. Proc Natl Acad Sci U S A. 2010;107(6):2550-2555.10.1073/pnas.0914508107

Chen HY, Fermin A, Vardhana S, Weng IC, Lo KF, Chang EY, Maverakis E, Yang RY, Hsu DK, Dustin ML, Liu FT. Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse. Proc Natl Acad Sci U S A. 2009;106(34):14496-14501.10.1073/pnas.0903497106

Maverakis E, Beech JT, Schneider S, Sercarz EE. Presentation of a determinant by MHC class II can be prevented through competitive capture by a flanking determinant on a multideterminant peptide. J Autoimmun. 2008;31(1):59-65.10.1016/j.jaut.2008.02.004

Wadhera A, Maverakis E, Mitsiades N, Lara PN, Fung MA, Lynch PJ. Thymoma-associated multiorgan autoimmunity: a graft-versus-host-like disease. J Am Acad Dermatol. 2007;57(4):683-689.10.1016/j.jaad.2007.02.027

Menezes JS, van den Elzen P, Thornes J, Huffman D, Droin NM, Maverakis E, Sercarz EE. A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE. J Clin Invest. 2007;117(8):2176-2185.10.1172/JCI28277

Maverakis E, Lynch PJ, Fazel N. Acrodermatitis enteropathica. Dermatol Online J. 2007;13(3):11

Maverakis E, Fung MA, Lynch PJ, Draznin M, Michael DJ, Ruben B, Fazel N. Acrodermatitis enteropathica and an overview of zinc metabolism. J Am Acad Dermatol. 2007;56(1):116-124.10.1016/j.jaad.2006.08.015

Kwak J, Maverakis E. Epidermolytic hyperkeratosis. Dermatol Online J. 2006;12(5):6

van den Elzen P, Menezes JS, Ametani A, Maverakis E, Madakamutil L, Tang XL, Kumar V, Sercarz EE. Limited clonality in autoimmunity: drivers and regulators. Autoimmun Rev. 2004;3(7-8):524-529.10.1016/j.autrev.2004.07.008

Sercarz EE, Maverakis E. Recognition and function in a degenerate immune system. Mol Immunol. 2004;40(14-15):1003-1008.10.1016/j.molimm.2003.11.002

Sercarz EE, Maverakis E. Mhc-guided processing: binding of large antigen fragments. Nat Rev Immunol. 2003;3(8):621-629.10.1038/nri1149

Sercarz E, Maverakis E, van den Elzen P, Madakamutil L, Kumar V. Seven surprises in the TCR-centred regulation of immune responsiveness in an autoimmune system. Novartis Found Symp. 2003;252:165-171; discussion 171-166, 203-110

Robinson WH, Fontoura P, Lee BJ, de Vegvar HE, Tom J, Pedotti R, DiGennaro CD, Mitchell DJ, Fong D, Ho PP, Ruiz PJ, Maverakis E, Stevens DB, Bernard CC, Martin R, Kuchroo VK, van Noort JM, Genain CP, Amor S, Olsson T, Utz PJ, Garren H, Steinman L. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol. 2003;21(9):1033-1039.10.1038/nbt859

Maverakis E, Beech J, Stevens DB, Ametani A, Brossay L, van den Elzen P, Mendoza R, Thai Q, Macias LH, Ethell D, Campagnoni CW, Campagnoni AT, Sette A, Sercarz EE. Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC. Proc Natl Acad Sci U S A. 2003;100(9):5342-5347.10.1073/pnas.0936151100

Elewaut D, Lawton AP, Nagarajan NA, Maverakis E, Khurana A, Honing S, Benedict CA, Sercarz E, Bakke O, Kronenberg M, Prigozy TI. The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells. J Exp Med. 2003;198(8):1133-1146.10.1084/jem.20030143

Ria F, van den Elzen P, Madakamutil LT, Miller JE, Maverakis E, Sercarz EE. Molecular characterization of the T cell repertoire using immunoscope analysis and its possible implementation in clinical practice. Curr Mol Med. 2001;1(3):297-304

Maverakis E, van den Elzen P, Sercarz EE. Self-reactive T cells and degeneracy of T cell recognition: evolving concepts-from sequence homology to shape mimicry and TCR flexibility. J Autoimmun. 2001;16(3):201-209.10.1006/jaut.2000.0493

Abromson-Leeman S, Maverakis E, Bronson R, Dorf ME. CD40-mediated activation of T cells accelerates, but is not required for, encephalitogenic potential of myelin basic protein-recognizing T cells in a model of progressive experimental autoimmune encephalomyelitis. Eur J Immunol. 2001;31(2):527-538.10.1002/1521-4141(200102)31:2<527::AID-IMMU527>3.0.CO;2-D

Wilson SS, van den Elzen P, Maverakis E, Beech JT, Braciak TA, Kumar V, Sercarz EE. Residual public repertoires to self. J Neuroimmunol. 2000;107(2):233-239

Maverakis E, Mendoza R, Southwood S, Raja-Gabaglia C, Abromson-Leeman S, Campagnoni AT, Sette A, Sercarz EE. Immunogenicity of self antigens is unrelated to MHC-binding affinity: T-cell determinant structure of Golli-MBP in the BALB/c mouse. J Autoimmun. 2000;15(3):315-322.10.1006/jaut.2000.0436

Maverakis E, Beech JT, Wilson SS, Quinn A, Pedersen B, Sercarz EE. T cell receptor complementarity determining region 3 length analysis reveals the absence of a characteristic public T cell repertoire in neonatal tolerance. The response in the "tolerant" mouse within the residual repertoire is quantitatively similar but qualitatively different. J Exp Med. 2000;191(4):695-702