Showing posts with label Lab Members. Show all posts
Showing posts with label Lab Members. Show all posts

Wednesday, October 30, 2024

Stephanie Le MD




Stephanie Le MD is a board-certified dermatologist, specializing in medical and procedural dermatology. She is a Southern California native and is honored to offer quality care to her home state. She completed her undergraduate degree at UCLA, where she was inducted into the Alpha Lambda Delta & Phi Eta Sigma Honor Society. She relocated to the East Coast to attend EVMS, where she completed medical school and a master’s degree in biomedical sciences. As a medical student, she was inducted into the Gold Humanism Honor Society for her exemplary compassionate patient care. She then completed her dermatology training at the University of California, Davis as their first American Board of Dermatology-approved investigative training track resident. This track is designed to support physicians who have a commitment to investigative and academic dermatology. Stephanie Le also completed a postdoctoral translational research fellowship and postgraduate training in complex medical dermatology at UC Davis, focused on innovative treatments and care of severe immune-mediated skin diseases.


Given her background, Dr. Stephanie Le has expertise in treating patients suffering from debilitating and complex skin diseases, often through enrollment in state-of-the-art clinical trials. She has served as the principal investigator and sub-investigator for a number of investigator-initiated phase I, II, and III clinical trials and pharmaceutical-sponsored trials, leading many as the top national or worldwide enrolling site. To support these endeavors, she has received grant support from the National Eczema Association, Women’s Dermatologic Society, and the National Psoriasis Foundation. Many of the studies that she participates in have been also funded by the. U.S. National Institutes of Health. For her many research accomplishments, she was honored as the sole recipient of the 2023 American Dermatologic Association Resident Research Award. She maintains an active research program at the UC Davis Department of Dermatology  as a volunteer clinical instructor. 

 

Dr. Stephanie Le values integrating medical and procedural dermatology to produce individualized and natural results for her patients. She served as the UC Davis Resident Chief of Cosmetic Education and has received awards and funding to support her cosmetic education from the American Society for Dermatologic Surgery, American Society for Laser Medicine and Surgery and the Cosmetic Bootcamp Vic Narurkar, MD Memorial. She has rotated and received training from some of the top aesthetic and procedural dermatologists.


Stephanie Le has a long-standing interest in patient-oriented and translational research, authoring 60 peer-reviewed, manuscripts in high impact journals such as Nature Reviews Disease Primers, JAMA Dermatology, the British Journal of Dermatology, and JCI Insight. Her research has focused on understanding the pathophysiology of immune-mediated diseases involving the skin and analysis of “omic” datasets (transcriptomic, glycomic, and lipidomic). She has also worked on developing novel therapeutic regimens and improved outcome measures for rare immune-mediated diseases, especially pyoderma gangrenosum, bullous pemphigoid, pemphigus vulgaris, and SJS/TEN. Stephanie Le has led structured exercises to obtain consensus among international experts on various topics in dermatology, including supportive management of Stevens-Johnson syndrome/toxic epidermal necrolysis.


Outside of the office, Dr. Le loves to travel, explore new restaurants and exercise.

Tuesday, January 10, 2017

Guillaume Luxardi, PhD




Experience



Post-Doc Scholar

UC Davis School of Medicine Dept. of Dermatology
 – Present (3 years 1 month)Institute for Regenerative Cures
The research I am performing is allowing me to acquires expertise in Immunology and Cancer Biology. We are currently designing genetically engineered T Cells and analyzing the phenotypes induced on Melanoma cells

Post-Doc Scholar

UC Davis School of Medicine Dept. of Dermatology
 –  (2 years 6 months)Institute for Regenerative Cures
The research I undertake allow me to acquires an interdisciplinary approach combining embryology, genetics, cell and molecular biology with electrophysiology in the context of animal development and regeneration. I am focusing on the integration of bio-physical and bio-chemical cue during tissue repair and regeneration as well as pattern formation during animal development.

ATER (non tenure track Faculty)

Aix-Marseille University
 –  (1 year)Developmental Biology Institute of Marseille-Luminy
Lecture and laboratory courses in Cellular biology to Bachelor and Master Students in Biology.

The research I undertook focuses on elucidating the biological functions and integration of BMP, FGF, Nodal and Notch signals during differentiation and morphogenesis in the Xenopus embryo.

Monitor / PhD student

Aix-Marseille University
 –  (3 years 1 month)Developmental Biology Institute of Marseille-Luminy
The research I undertook focuses on elucidating the biological functions and integration of BMP, FGF, Nodal and Notch signals during differentiation and morphogenesis in the Xenopus embryo.

Lecture and laboratory courses in Drosophila genetics to Bachelor Students in Biology

Graduate Research Assistant

Aix-Marseille University
 –  (4 months)Developmental Biology Institute of Marseille-Luminy
The research I undertook focuses on the establishment of mono layer murine Embryonic Stem Cell (ESC) culture and neural differentiation and on the description of the expression pattern of glypicans genes in mice embryonic and new born brain

Michiko Shimoda, PhD



Position: Assistant Professor, Co-Director Immune Monitoring Shared Resource

PROFILE


Immunologist with over 20 years of experience in broad human and mouse immunology with emphasis in B cell biology and antigen presenting cell functions. Conducted basic and translational research projects in the area of vaccine, autoimmune diseases and cancers with various animal disease models in academic and private institutes.

RESEARCH INTEREST

* Glycans as a tool to modulate immune response

* To identify and characterize natural glycans (human milk glycans and plant glycans) that can modulate antigen-presenting cell function and differentiation.

* To identify key signaling events in immune cells induced by glycans, which are required for glycan-mediated immune modulatory functions.

* To test immune modulatory functions of glycans in animal models of cancers, autoimmune diseases, or in vaccination.

* Immune monitoring of patients with cancers and autoimmune diseases

RESEARCH EXPERIENCE

University of California at Davis, School of Medicine, Department of Dermatology,
Assistant Adjunct Professor

* The anti-inflammatory role of human milk glycans.

* Characterization of anti-inflammatory functions of human milk glycans.

* Identification of key signaling events in human dendritic cells induced by glycans, which are required for glycan-mediated anti-inflammatory functions.

(manuscript in preparation)

* Glycans as a tool for immune therapy

* Identification and characterization of natural glycans (human milk glycans and plant glycans) to modulate myeloid lineage cell function and differentiation.

Medical College of Georgia, School of Medicine,
Assistant Professor

* B cell antigen presentation in immune responses.

* Employed unique B cell restricted MHC-II conditional knockout mice to help understanding the role of B cell antigen presentation in immune response.


Utsunomiya University, Utsunomiya, Japan
Instructor

* Repertoire analysis of mucosal IgA response

* Generated over 20 IgA clones from murine Peyers’ patches using hybridoma technology.

* Characterized mucosal IgA repertoire specificity.

* Understanding the mechanism of memory B cell generation during immune response

* Studied the mechanism of high-affinity B cell selection in germinal centers.


University of Tokyo, Tokyo University of Agricultural and Technology, Tokyo, Japan
PhD

* Understanding the mechanism of high-affinity memory B cell generation for mucosal vaccine development.

* Demonstrated for the first time that high-affinity IgA memory B cells are generated through germinal center response in mucosal associated lymphoid tissues.


INDUSTRY EXPERIENCE

Research Center for Allergy and Immunology, RIKEN, Yokohama, Japan

Research Scientist

Morinaga Milk Industry CO., Tokyo, Japan

Research Scientist

TECHNICAL SKILLS

* Flowcytometry: FACSCanto, FACSFortessa and FACSAriam with multiplex flow cytometry for immune- subset markers with intracellular cytokine staining, phospho- specific flow cytometry.

* Immune-monitoring assays: ELISA assays, ELISPOT and Luminex assays.

* Immune histochemistry.

* Molecular Biology: General molecular biology techniques including PCR, quantitative RT-PCR, cloning and mutagenesis.

* Protein purification: HPLC, gel electrophoresis analysis, Western blotting.

* Antibody production: animal immunization, cell culture, hybridoma generation.

* Animal handling: mouse, rat, guinea pig, and rabbit.

* Animal models: experimental autoimmune encephalomyelitis, colitis, T1 diabetes, skin transplantation, adoptive lymphocyte transfer, bone marrow transfer, xenograft cancers (B16 melanoma, PEL and NHL).

EDUCATION

* Ph.D. Tokyo University of Agriculture and Technology
Tokyo, Japan (2002) Mucosal Immunology

* PhD course University of Tokyo
Tokyo, Japan (1990-1991) Molecular Biology

* MS University of Tokyo, Tokyo, JAPAN
Tokyo, Japan (1984-1986) Agricultural Biochemistry


AWARDS, HONORS AND FELLOWSHIPS

* Research Award (Immunology) by Becton Dickinson to study autoimmune skin diseases.

* Travel Grants from the American Association of Immunologist for attending the annual meetings and International Congress of Immunology

* Travel Grants from the NIAID to attend an annual American Association of Immunologist meeting.

* Presidential Guest Scientist of Tokyo University of Scientist in support with international collaboration on immune regulation.

* Fellowship for young overseas researchers from Japanese government in support with visiting research activity in Dr Garnett Kelsoe’s laboratory, University of Maryland.

GRANTS

* Seed grant Shimoda, M. (PI) 6/01/2016 – 05/31/2017 (UC Davis Dermatology)
“Characterizing sialyl milk oligosaccharides with anti-inflammatory functions” The major goal of this project is to characterize milk oligosaccharides with anti-inflammatory functions using in vitro culture of human dendritic cells.

* PSRP00054 Shimoda, M. (PI) 10/01/2011 – 09/30/2012 (MCG Pilot Study Research Program)
“Regulatory function of IL-10-producing CD8 T cells in immunity and autoimmunity” The major goal of this project was to define the regulatory role of IL-10 producing CD8 T cells in mouse T1 diabetes model.

* NIAID R21 AI064752-01A2 Shimoda, M. (PI) 09/30/2007 – 08/31/2011 (NIH/NIAID)
“Long-lived plasma cell differentiation” The major goal of this project was to define the role of MHC-II-restricted antigen presentation in long-lived plasma cell differentiation of memory B cells.

* NIAMS R03 5R03AR52470-2 Shimoda, M. (PI) 3/01/06-2/28/11 (NIH/NIAMS)
“B cell antigen presentation in models of B cell autoimmunity” The major goal of this project was to understand the role of MHC-II and CD40/CD40L signals in a mouse model of B cell autoimmunity.

* MCGRI grant Shimoda, M. (PI) 10/01/09-09/30/10 (Medical College of Georgia)
“Autonomous CD40 signaling in lymphomagenesis” The aim was to study the role of constitutive CD40 signaling in B malignancy.

* Matuszak Foundation for lupus research Shimoda, M. (PI) 09/01/2008 – 08/30/2009 (Matuszak Foundation, Medical College of Georgia)
“Role of stromal cell surface heat shock proteins in Lupus” The aim was to test the hypothesis that HSP90/DNA complexes displayed on the surface of dying cells trigger B cells to make self-reactive antibodies.

* MCGRI grant Shimoda, M. (PI) 08/01/04-07/31/06 (Medical College of Georgia)
“MHC-II dependent antigen presentation in long-lived plasma cell differentiation” Studies of the role of B cell MHC-II in the differentiation of long-lived plasma cells in bone marrow.

* Grant-In-Aid Shimoda, M. (PI) 04/01/02-03/31/03 (Japanese government)
“Genetic analysis of B cell memory response in LT-beta knock-out mice” The aim was to study follicular dendritc cell (FDC) function B cell memory response generation by analyzing LT-beta knockout mice, which form germinal centers without FDC networks.

NCBI bibliography

Alina Marusina, PhD

Experience 




Assistant Researcher

UC Davis
 – Present (5 years)
Reserach

Monday, January 9, 2017

Emanual Maverakis, MD



Emanual Maverakis, MD-    Principal Investigator

Dr. Maverakis runs a UC Davis clinic that specializes in the treatment of patients with severe immune-mediated diseases involving the skin and skin cancers such as melanoma and cutaneous T cell lymphoma. He is also an immunology researcher who holds early career awards from the Howard Hughes Medical Institute and the Burroughs Wellcome Fund.
“In order to gain insight into the pathogenesis of autoimmunity the first step is to identify and characterize the T cells involved.”
Dr. Maverakis became interested in immunology as an undergraduate at the University of California-Los Angeles where he earned departmental honors for his work on a mouse model of multiple sclerosis, experimental autoimmune encephalomyelitis. He then continued his research endeavors at Harvard Medical School (HMS) in Boston where he graduated summa cum laude in 2003. He is in a elite group of only 15 students in over 220 years to have graduated with highest honors from HMS. After completing an internship in internal medicine at Harvard’s Beth Israel Deaconess Medical Center, Dr. Maverakis came to UC Davis to complete a residency in dermatology and in 2007 he joined the faculty. He holds appointments in the Department of Dermatology and in the Department of Medical Microbiology and Immunology. 
His lab investigates the pathophysiology of autoimmunity, how T cells (a type of white blood cell) develop and mature, and cancer immunotherapy.  His group is also interest in how foods interact with our immune system; how the immune system recognizes cancer, especially melanoma; developing novel hydrogels, especially with regards to delivering stem cells and immunotherapeutics; clinical trial design, and outcome measures.  Some diseases of special interest include psoriasis, scleroderma, pyoderma gangrenous, pemphigus vulgaris, bullous pemphigoid, melanoma, and cutaneous T cell lymphoma.  

Education
B.S. Microbiology and Molecular Genetics-                 University of California, Los Angeles
M.D. Medicine with special studies in Immunology-                        Harvard Medical School

Honors and Awards
MD Summa Cum Laude, Harvard Medical School | NIH Director's New Innovator Award, National Institutes of Health | Career Award for Medical Scientists, Burroughs Welcome Fund | Physician-Scientist Career Award, Howard Hughes Medical Institute | PECASE, President Barack Obama