Tuesday, August 18, 2015

Dual mTOR inhibition and Scleroderma

Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma




In this article we demonstrated that dual mTOR inhibition can prevent TGF-beta-inudced fibrosis.  These results have implications for scleroderma. 

 2015 Jul 2. doi: 10.1038/jid.2015.252. [Epub ahead of print]



29 comments:

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    1. This is my testimony about the good work of DR.OCUSODO who helped me.... I'm from texas USA. And am sorry for putting this on net but i will have to, by this world best spell caster that brought back my husband who left me out for past 3 years, i eventually met this man on a blog site posting by one of is client for help, i explained everything to him and he told me about a spell caster that he had heard about and he gave me an email address to write to the spell caster to tell him my problems. In just 2 days, my husband was back to me. I just want to say thank you to this truthful and sincere spell caster, sir all you told me have come to pass and thank you sir. Please I want to tell everyone who is looking for any solution to their problem, I advise you to kindly consult this spell caster, he is real,he is powerful and whatever the spell caster tells is what will happen, because all what the spell caster told me came to pass. You can kindly contact him on: his email address is drocusodospellcaster@gmail.com OR drocusodospellcaster@yahoo.com or directly on whats-app +2347066448668        

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    2. DR EMU WHO HELP PEOPLE IN ANY TYPE OF LOTTERY NUMBERS
      It is a very hard situation when playing the lottery and never won, or keep winning low fund not up to 100 bucks, i have been a victim of such a tough life, the biggest fund i have ever won was 100 bucks, and i have been playing lottery for almost 12 years now, things suddenly change the moment i came across a secret online, a testimony of a spell caster called dr emu, who help people in any type of lottery numbers, i was not easily convinced, but i decided to give try, now i am a proud lottery winner with the help of dr emu, i won $1,000.0000.00 and i am making this known to every one out there who have been trying all day to win the lottery, believe me this is the only way to win the lottery.

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  2. I was able to get rid of my herpes virus this year, i was diagnosed of herpes virus since late 2015 and i was on my doctor prescription ever since i have the virus, I wasn’t satisfied i needed to get the virus out of my system and get rid of the virus,i was going through a blog to find new informations about the Herpes Simplex Virus i came across a review of a lady who was testify on the  cured that the great herbalist cured is virus and  i have to contert him and see what he told me to do for me to get rid of the cure I contacted the herbal foundation and they guided me on how to purchase the herbal formula. the herbal products las me for 3 weeks which helps me to get rid of the virus totally, for easy communication you can reach Dr Freeman Osas on his WhatSapp via +2347057052206 email. balogospellcaster@gmail.com     

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  3. Hey everyone. I just wanna tell y’all that I’ve been cured from herpes virus. It only took me Two weeks to be cured finally from this virus and what I did definitely got me cured completely from my HSV2, I’m so happy . When every odd seems to be against me i trusted in the lord. I battled for so long until a friend introduced me to Doctor Kham who was finally able to help me and here i am today healthy and strong. Email this herbalist via dr.khamcaregiver@gmail.com that is his contact details.

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  4. HERBAL DR EMU WHO PREPARE HERBAL MEDICINE TO CURE ALL KINDS OF DISEASES INCLUDING HERPES DISEASE.   
     I have been battling this Herpes disease for almost 3 years now....I tried all possible means to get cure from my Herpes Disease but all to be in vain until i saw a post in a health forum about a herbal Dr Emu who prepare herbal medicine to cure all kind of diseases including Herpes Disease, at first i doubted if it was real but decided to give it a try...when i contact Dr Emu via his email (emutemple@gmail.com)  write him and reply me explain how the process work so after ordering for the medicine I got it within 3/4 working days through DHL Delivery and I took it according to the way Dr Emu instructed, I was so happy after 2 week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative...Herpes patients should also get in touch with this herbalist Dr Emu to get rid of these Herpes Virus forever his whatsapp number +2347012841542.

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  5. My name is Brittney Brian,i am from Arizona, Its a pleasure for me to write this testimony about how i got my Genital Herpes cured 2 months ago. i have been reading so many comments of some people who were cured from various diseases by Dr. Festus, I was hurt and depressed so I was too curious and wanted to try Dr. Festus cuz have been burdened by this virus for many , then i contacted him through his email when i contact him, he assured me 100% that he will heal me, i pleaded with him to help me out which he did, he healed me just as he promised, he sent me his medication and ask me to go for check up after 5 weeks of taking the medication. i agreed with him i took this medication and went for check up, to my greatest surprise my result was negative after the treatment, i am really happy that i am cured and healthy again. I have waited for 5 weeks after I first tested negative just to be very sure i was completely healed before writing this testimony I just got back from the hospital today from getting my blood test result and am still negative, so i guess its time i recommend anyone going through Herpes HSV-1 or HSV-2, HIV, HPV, Hepatitis A&B, Diabetes, Cancer reach him through Email drfestusherbalsolutioncentre@gmail.com OR add on whatsapp +2348073742265.

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  6. HOW I GOT CURED FROM  DIABETES BY DR MUSTAFA.  Hello, my name is Eric Jackson. I'm from USA , I have been suffering from DIABETES for the past years and I have constant pain, At first I had faith in God that I would be healed , but the virus circulated all over my body while taking treatment from my Doctor. Few weeks ago I saw testimonies of people who have been cured from various diseases like  HEPATITIS B, HIV/AID, FIBROIDS,HSV, ALS HPV and CANCER by a traditional healer called Dr, Mustafa. I read further and saw his Email address and phone number. I contacted him via the email address and told him about my ailment he then told me not to worry that i will be cured from the disease(DIABETES) i never believed it at first but later i decided to give it a trial, after all the procedures and remedy given to me by this man, few weeks later i started experiencing changes all over my body just as the Doctor has assured me that i will be cured,after taking his herbal medicine for weeks i went for checkups my Doctor confirmed that there were no trace of the ailment again i was cured totally from the disease with the herb from Dr.mustafa. You can contact him on his email; heralremedies21@gmail.com or call, what-app on+2347010821863. for help on any kind of disease/virus and also to get your lover back for further information visit his website drmustafa.online.

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  8. Hi viewers, I'm posting this Because i found lots of people having marriage and relationship and divorce problems, which I also experienced. I recently found help from a man called Dr. Oselumen he did a great job that made my husband fell back in love with me after ten months of separation. I want y' all to know there are fake online spell Dr.s if someone out there needs help, can easily contact droselumen@gmail.com or reach him on whatsapp +2348054265852 he will give you the best result.

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  9. I found out, that taking herbal treatment is the best to get rid of hpv as soon as i feel the symptoms of hpv is appearing, i took the healing process by contacting Dr onokun for natural treatment it works wonders, amazingly ever since I had the herbal treatment i have not feel these horrible disease anymore and my doc told me the virus is gone, i am glad i finally got cured out from this horrible disease. every hpv or herpes patients should also get in touch with this herbalist Dr to get ride of these disease forever. his Email: Dronokunherbalcure@gmail.com

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  10. First, I want to complement this page administrator for creating this platform for us to express our feelings. HPV is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with hpv is by taking natural herbs medicine from DR. Agbomian the greatest herbalist doctor in the world and is only few American doctors that know about this herbal medicine from Dr Agbomian .. I have read about Dr Agbomian the great herbalist doctor from African who can cure disease with his powerful herbal medicine. for the people suffering from the following diseases, Herpes,HIV/Aids, Cancer, Also, Hepatitis, Diabetes, Hpv, Infections ETC should contact him for his herbal medicine because i am a living testimony and i was cured of herpes. Although, i sent him what he requested and he sent me his medicine through DHL courier delivery company which i took for some days and today when i went for test, i was tested HPV negative. you can reach him through his Email: Dragbomianherbalcured77@gmail.com

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  11. I'm so excited my broken Marriage has been restored. My ex husband is back after he left me and our 2kids for another woman. I was so happy to meet Dr. OKu how he helps many people to bring their Lover back so i contact him to help me too. husbandThat was how Dr. Oku helped me to bring my  back.. A big thank you to Dr. Oku because I never thought my ex Husband will be back to me so quickly with your spell. You are the best and world greatest. If you are here and you need your Ex Lover back or your husband moved to another woman, do not cry anymore, contact this powerful spell caster now. Here’s his contact:Email him at: okutemple@gmail.com You can also Call/WhatsApp:+2348163425519

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  12. I'm so excited my broken Marriage has been restored. My ex husband is back after he left me and our 2kids for another woman. I was so happy to meet Dr. OKu how he helps many people to bring their Lover back so i contact him to help me too. husbandThat was how Dr. Oku helped me to bring my  back.. A big thank you to Dr. Oku because I never thought my ex Husband will be back to me so quickly with your spell. You are the best and world greatest. If you are here and you need your Ex Lover back or your husband moved to another woman, do not cry anymore, contact this powerful spell caster now. Here’s his contact:Email him at: okutemple@gmail.com You can also Call/WhatsApp:+2348163425519

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  13. Life is always beautiful when you are in good health. For almost 4 years I have been with herpes and I was lonely and sad. Fortunately I turned to a good and great doctor. to help me get back to health. completely cured my herpes.Today I am herpes free and very healthy. Many thanks. Dr ubarlo For returning my health. I will always be grateful. Dr ubarlo If you are reading this testimong and you have some kind of illness.(1) hepatitis.(2)cancer.(3) HIV.(4)herpes.(5) fibroids.6) ) (7) Cancer diabetes, you can also contact him on his email address drubarlohome@gmail.com or Whatsapp +2348119508814

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  14. This is my testimony about the good work of DR.OCUSODO who helped me.... I'm from texas USA. And am sorry for putting this on net but i will have to, by this world best spell caster that brought back my husband who left me out for past 3 years, i eventually met this man on a blog site posting by one of is client for help, i explained everything to him and he told me about a spell caster that he had heard about and he gave me an email address to write to the spell caster to tell him my problems. In just 2 days, my husband was back to me. I just want to say thank you to this truthful and sincere spell caster, sir all you told me have come to pass and thank you sir. Please I want to tell everyone who is looking for any solution to their problem, I advise you to kindly consult this spell caster, he is real,he is powerful and whatever the spell caster tells is what will happen, because all what the spell caster told me came to pass. You can kindly contact him on: his email address is drocusodospellcaster@gmail.com OR drocusodospellcaster@yahoo.com or directly on whats-app +2347066448668        

    ReplyDelete
  15. I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
    liver already present. I started on antiviral medications which
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    the 6 months long treatment and tested negative to the virus. Amazing
    treatment! This treatment is a breakthrough for all HBV carriers.

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  17. DR EMU WHO HELP PEOPLE IN ANY TYPE OF LOTTERY NUMBERS
    It is a very hard situation when playing the lottery and never won, or keep winning low fund not up to 100 bucks, i have been a victim of such a tough life, the biggest fund i have ever won was 100 bucks, and i have been playing lottery for almost 12 years now, things suddenly change the moment i came across a secret online, a testimony of a spell caster called dr emu, who help people in any type of lottery numbers, i was not easily convinced, but i decided to give try, now i am a proud lottery winner with the help of dr emu, i won $1,000.0000.00 and i am making this known to every one out there who have been trying all day to win the lottery, believe me this is the only way to win the lottery.

    Dr Emu can also help you fix this issues

    (1)Ex back.
    (2)Herbal cure & Spiritual healing.
    (3)You want to be promoted in your office.
    (4)Pregnancy spell.
    (5)Win a court case.

    Contact him on email Emutemple@gmail.com
    What’s app +2347012841542
    Website Https://emutemple.wordpress.com/
    Facebook page Https://web.facebook.com/Emu-Temple-104891335203341

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  18. Dr. Ero Natural Remedies is The Best, It Helps Me to Eradicate My Herpes Virus Just in Two Weeks....... Why go to expensive treatment in hospitals whereby Dr Ero Natural Remedies is here to clean you from Herpes and many more illnesses … I had Herpes for 9 months they all tell me there was no cure for me I have go to different hospital I always have same news, I was confused because I feel like ending my life but i thank God I was able to locate herbal doctor Ero who help me I found his email on site how people was writing Good about him I never believe he can really cured me until when I get my test done. I am so happy to tell you this herbal doctor Ero has a herbal cure for Herpes and you can take the medicine according to his instructions. You will find out that you will give testimony like me. I took his herbal medicine for just 2 week. I am so happy today that I am really free from this sickness. Here is herbal doctor Kham email dreromoncaregiver@gmail.com or Whatsapp: +2348140916349

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  19. I use to be a very poor woman who has always not find luck when it comes to playing the lottery. I have been playing lottery since i was 21 years and now i am 45 meaning i have been playing lottery for 24 years. The biggest amount i have ever won in my life was 400 bucks. But one day my story turns to history after i find this man name on the Internet that he is the best when it comes to winning lottery. This man is a very strong voodoo doc who gives out the numbers that can never fail. After all my years of laboring and struggling to win the lottery i finally won ( $27,000,000) Dr Alli is the name, Email: allispellhelp1@gmail.com or contact him on his whatsApp number +2348100772528 this is the only way to win the lottery and the best way

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  20. The doctors said Herpes virus do not have medical cure because the virus is capable of hiding within the human cells, it remains protected from your immune system. Herpes isn’t a special virus – your immune system has the tools to fight it back. But because it is able to lay dormant in protected cells, your immune system is unable to remove it from your body,But with strong reactive herbal medication is capable of getting rid of the virus gradually and totally from your body without damaging any of your cells,natural herbs kills the virus totally not just reducing the out break. Get natural herbs cure Email DR. VOODOO at voodoospelltemple66@gmail.com Add Dr voodoo on whatsApp +2348140120719

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  21. powerful herbal healer called Dr. voodoo who use his natural herbs to cure
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  23. I want to share this great testimony to the world on how Dr VOODOO cure me from HSV1&2 with his herbs, I was nervous when i first contact him about the cure for HSV but i decided to give him a try because i was desperate to get cured and be free from HSV. Dr VOODOO prepared the remedy and sent it to me through UPS,which I use just the way Dr VOODOO instructed me and thank God today I am a beneficiary to this cure and I went back to the hospital after 7 days of taking the herbs and I tested HSV1&2 Negative. So I will tell you all who are looking for a cure to his/her HSV1&2 that Dr VOODOO took research before he could finally get the solution to it and a lot of people are benefiting from him right now. He also cured my friend from HPV. Dr VOODOO heals with natural herbs. Please I urge you to contact him now through his email address: voodoospelltemple66@gmail.com or call and WhatsApp him on +2348140120719. He is capable of curing HIV/AIDS, HERPES, HPV, HSV1&2, CANCER of all kinds, DIABETES and so many other infections.

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  25. HOW I GOT CURED FROM HERPES VIRUS

    I was diagnosed with the HERPES virus and I have tried everything possible to cure myself, but all to no avail, until I saw a post in a health forum about a doctor preparing herbal medicines to cure HERPES virus, at first I doubted it was real, but decided to give it a try, when I contacted this Doctor on whatsapp (+2348180828544) and he prepared medicine and sent it to me with the help of DHL delivery company, when I received this herbal medicine, he gave me step-by-step instructions on how to apply it, after applying it the way they directed me, I was totally cured of this deadly disease called HERPES, all thanks to Dr. Ishiaku

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  26. Hi Friends i am so glad to writing this article today to tell the world how Dr voodoo cured my HSV VIRUS,i have been detected with HSV-1 AND HSV-2 since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn't cure my HSV VIRUS neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr voodoo the powerful herbalist that cure numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his whatsApp number at +2348140120719 or email: voodoospelltemple66@gmail.com i explained everything to him and prepared a cure that cure my HSV-1 AND HSV-2 disease totally after receiving his herbal medicine, so my friends viewers why wait and be suffer when there is someone like Dr voodoo that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS, you can contact his via : voodoospelltemple66@gmail.com or WHATSAPP +2348140120719

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  27. I love playing the Lottery and I buy tickets every 2 weeks after I get paid. I never wanted to get greedy but I did want enough to live more comfortably. Generally, my luck is pretty terrible. I took a chance when I found a website called [ amberlottotemple.com ] that offers spells to help people. It was the best £415 Pounds I have ever spent! I had to save up for a couple of weeks to be able to afford the spell. I had the spell targeted towards the National Lottery. I heed to DR Amber instructions to buy the ticket after 3days and have faith that I would be the winner. I kept my faith very strong just as DR Amber told me to do. The next morning I got up and saw an email from the National Lottery saying, "Good news, you've won a prize". Today my wife and I are proud winners of £184,262,899.10 Million Pounds. We are here to Appreciate the good deeds of DR Amber. You can reach out to him by email .…. amberlottotemple@yahoo.com

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