Thursday, February 8, 2018

Gamma Delta T cells protect against Staph aureus



Gamma Delta T cells protect against Staph aureus

Need to characterize an immune response? My research team specializes in developing novel bioinformatic methods to analyze RNA-Seq datasets for immune genes and in performing dedicated T cell receptor gene sequencing. Take a look at our recent article in the Journal of Clinical Investigation, which demonstrates how gamma delta T cells provide long-term protection against Staph aureus. This project was based out of Lloyd Miller's laboratory at Johns Hopkins University.  Dr. Miller is an expert in Staph aureus and wanted to the study anti-Staph immune responses.  For Dr. Miller our research team used our in-house developed bioinformatics pipeline (TCRminer) to correlate the expression of T cell receptor genes with other immune genes of interest.  We also performed dedicated TCR sequencing to answer fundamental questions about how the immune system responds to Staph.  Please see the link to the article and please contact us if this type of analysis can be of use in your research. We are especially interested in immune monitoring in the setting of immunotherapy and autoimmunity. Collaborative studies are most welcome.